Episode 82: Lost faith in surrogates yet? ACCORD challenges beliefs again

Submitted by admin on Wed, 2010-04-07 18:11

In episode 82, James and Mike discuss the latest results from the ACCORD trial. While the results really showed no difference between the groups, these results should make a difference in what you do. During much of the podcast, Mike does an unbelievable impersonation of a parrot but, we aren't sure if anyone will notice that difference.

Show notes

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Comments

The "treat and forget" statin

Submitted by gnomon (not verified) on Thu, 2010-04-08 13:25.

The "treat and forget" statin approach is formalized and validated in a very interesting simulation study published in Annals of Internal Medicine. Hayward et al compared the usual treat-to-target approach with a risk-driven stategy (moderate dose/potency statin for moderate CAD risk, high dose/potency statin for high CAD risk) with no subsequent agonizing over target levels. The estimated benefits of the risk-driven strategy were prevention of more CAD events while treating fewer persons with high-dose statins than
the treat-to-targetapproaches.

Hayward RA, Krumholz HM, Zulman DM, Timbie JW, Vijan S.
Optimizing statin treatment for primary prevention of coronary artery disease.
Ann Intern Med. 2010 Jan 19;152(2):69-77.

http://www.ncbi.nlm.nih.gov/pubmed/20083825

This podcast was really funny

Submitted by DavidSandhu (not verified) on Mon, 2010-04-12 22:37.

This podcast was really funny (and of course informative). I have never laughed out loud while listening to such useful information. Well done guys!

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