Episode 21: The Down-Low on Low Dose: The Logic

Submitted by admin on Thu, 2008-09-18 01:40

In our 21st episode we jump into our ongoing debate about low and very low dose of medication. We present the reason why initial doses of new drugs are often too high and the logic for trialing lower doses in patients. We also review over 10 examples of medications proven in randomized control trials to be equally effective (or more) at lower doses.

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Comments

Another crispy study on lowering BP with a low dose

Submitted by satarno on Tue, 2011-02-22 09:46.

Hi,
I found this interesting metanalysis that shows that- Low doses works better than higher doses - to control High blood pressure.
i quote the author's conclusion " First-line low-dose thiazides reduce all morbidity and mortality outcomes. First-line ACE inhibitors and calcium channel blockers may be similarly effective but the evidence is less robust. First-line high-dose thiazides and first-line beta-blockers are inferior to first-line low-dose thiazides."
Voila!
Wright JM, Musini VM. First-line drugs for hypertension. Cochrane Database Syst Rev. 2009(3):CD001841.

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