depression

depression

Episode 218: Shining a bright light on the Vitamin D evidence – Part II

In episode 218, Mike and James give you more and more Vitamin D love. We look at Vitamin D for MS, depression and upper respiratory tract infections and basically Vitamin D does nothing for these conditions - so go forth and share the love – which means not recommending Vitamin D for these conditions.

Show notes

1) The Calcium and Vitamin “Bible” Read more »

Episode 194: The evidence for Vitamin D and folic acid for depression is not all that depressing

In episode 194, Mike and James invite our good friend and colleague David Gardner to layout the evidence for folic acid and Vitamin D for depression. Because there isn’t a lot of definitive evidence we discuss how to make recommendations in the face of limited evidence. We decide that decisions often come down to the chance of harm and what other alternatives are available. Read more »

Episode 155: Antipsychotics for depression - is the news depressing?

In episode 155 Mike and James delve into the tricky area of the evidence around using antipsychotics as either monotherapy or augmentation for depression. We discuss that while there is evidence of benefit, the effect is not dissimilar to that seen with antidepressants. 

Show notes Read more »

Episode 106: Treating depression with the ultimate low-dose interventions

In episode 106, James and Mike welcome back our good friend and colleague from New Zealand, Bruce Arroll. Out of respect, we made sure there were no earthquakes during his visit because earthquakes, as we found out, can be somewhat depressing. Read more »

Drugectomies - DTC 2010

This week we have something slightly different for you. Read more »

Episode 44: Practice Changing Articles - with Double the Mikes

In Episode 44, we review another collection of practice changing articles and are joined by Dr. Mike Kolber. The first case and study considers the use of metformin in gestational diabetes and the trial leads to a longer discussion of the challenges of prescribing in pregnancy. The second case and study concerns the use of ondansetron for vomiting in pediatric patients. Read more »

Episode 16: Anti-Depressants: Is there a Drug of Choice?

In episode 16 we look at initiating treatment for depression. We briefly review screening and the diagnosis of depression before discussing the non-drug treatment options (therapy, exercise, sleep hygiene). We search for the anti-depressant of choice (being any) and end up deciding to tailor the choice based on factors such as side-effect profile, targeted symptoms, and cost. Read more »

Episode 15: Treating Depression: The Recent Sad News about Anti-Depressants

In episode 15 a guest assists us in addressing the evidence suggesting anti-depressants are not as effective as believed. We review some biases in the anti-depressant research including publication bias (how good studies are published more than bad studies). We discuss how the benefits of anti-depressants over placebo increase as the severity of depression worsens. Read more »

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